EFFECT OF MILK THISTLE (SILYBUM MARIANUM) AND BLACK COHOSH (CIMICIFUGA RACEMOSA) SUPPLEMENTATION ON DIGOXIN PHARMACOKINETICS IN HUMANS
نویسندگان
چکیده
منابع مشابه
Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humans.
Phytochemical-mediated modulation of P-glycoprotein (P-gp) and other drug transporters may underlie many herb-drug interactions. Serial serum concentration-time profiles of the P-gp substrate, digoxin, were used to determine whether supplementation with milk thistle or black cohosh modified P-gp activity in vivo. Sixteen healthy volunteers were randomly assigned to receive a standardized milk t...
متن کاملMilk Thistle (Silybum marianum)
Milk thistle is a well known and commonly used herb, used particularly in hepatic diseases. It has very potent antioxidant, anti-inflammatory, and antifibrotic properties (1). As a single agent its therapeutic effects in liver disease appear to be modest (2,3,4,5). Herbal medicines and supplements are likely to be much more beneficial when used synergistically in combinations or formulas. Milk ...
متن کاملEffect of milk thistle (Silybum marianum) on the pharmacokinetics of irinotecan.
PURPOSE Milk thistle (Silybum marianum) is one of the most commonly used herbal therapies, and its principal constituent silybin significantly inhibits cytochrome P450 isoform 3A4 (CYP3A4) and UDP glucuronosyltransferase isoform 1A1 (UGT1A1) in vitro. Here, we investigated whether milk thistle affects the pharmacokinetics of irinotecan, a substrate for CYP3A4 and UGT1A1, in humans. EXPERIMENT...
متن کاملIsolation of CYP3A4 Inhibitors from the Black Cohosh (Cimicifuga racemosa)
Recent investigation on drug interaction has shown that some foods and herbal medicines increase the oral availability of a variety of CYP3A4 substrates, which is caused by the reduction of CYP3A4 in intestinal epithelium. During the course of our investigation on CYP3A4 interaction, we found that the commercially available dietary supplement made from black cohosh (Cimicifuga racemosa) showed ...
متن کاملMuscle damage induced by black cohosh (Cimicifuga racemosa).
Extracts of black cohosh (Cimicifuga racemosa) are commonly used for the treatment of symptoms associated with menopause. Adverse events with black cohosh are rare, mild and reversible. A few number of serious adverse events, including hepatic and circulatory conditions, have been also reported, but without a clear causality relationship. We report the case of a woman with severe asthenia and v...
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ژورنال
عنوان ژورنال: Drug Metabolism and Disposition
سال: 2005
ISSN: 0090-9556,1521-009X
DOI: 10.1124/dmd.105.006312